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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Evaluation of Antidepressant Activity of Methanol and Petroleum Ether Extracts of Daucus Carota Ssp. Sativus Var. Atrorubens Alef. (Purple Carrot) Roots in Experimental Animals

Author: B.KRUPAVARAM , S.LASHINNA, HANISH SINGH JC, BVS.LAKSHMI, SHASHIDHARAN MENON, H.JAASMINERJIIT KA
Abstract: In traditional system Daucus carota ssp. is useful in treating various ailments. The objective of the study was to preliminary phytochemical screening and evaluate antidepressant effect of methanolic and petroleum ether extract of Daucus carota ssp. (purple carrot) roots in different behavioural models such as forced swimming test (FST), tail suspension test (TST) and open field test (OFT) in animal models. Preliminary phytochemical screening of methanol extract showed the presence of alkaloids, flavonoids, glycosides, phenols, proteins, amino acids, volatile oils and steroids. Petroleum ether extract showed the presence of alkaloids, flavonoids, glycosides proteins, amino acids, and volatile oils. Both the extracts (200 and 400 mg/kg) of were administered via oral route and studied behavioural studies by FST, TST and OFT models. In FST and TST, both the extracts were highly significant (p<0.001) by reducing the immobility duration in rats and mice respectively, almost comparable to standard drug (Fluoxetine 20mg/kg). Methanol extract of 200 mg/kg, showed less significant (p<0.05) in frequency of rearing activity compared to petroleum ether extract (400 mg/kg) in open field test. Methanol extract of 200 mg/kg showed significant (p<0.01) in frequency of lines crossing compared to standard drug, and frequency of head dippings in both the extracts showed highly significant (p<0.001) than Fluoxetine 20mg/kg. These results demonstrated that Daucus carota L. possesses antidepressant like effect in behavioural model. The present study warrants further investigations on the mechanism of action of purple carrot in the CNS, in both methanolic and petroleum ether extracts.
Keyword: Antidepressant, Daucus carota ssp. sativus var. atrorubens Alef., Forced swimming test (FST), Tail suspension test (TST), Open field test (OFT)
DOI: https://doi.org/10.31838/ijpr/2021.13.02.127
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