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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Fabrication and Characterization of Interpenetrating Polymer Network Matrices for Controlled Drug Delivery of Propranolol HCL Using Polymers Locust’s Bean Gum, Gelucire and Sodium Alginate

Author: MUNENDRA PAL, SWATI GAUTAM, SUKIRTI UPADHYAY, PRASHANT UPADHYAY
Abstract: Due to modification during its synthesis and enhancement that transforms new physicochemical and mechanical properties within the formulation; the Interpenetrating polymer network (IPN) has shown great interest in drug delivery. Based on literature survey, IPN research study was proposed which incorporates their methods of preparation and characterization parameters such as U.V and FTIR studies and in vitro release and animal studies using Wister rats. IPN beads are prepared for controlled release application using Propranolol HCl (an antihypertensive drug), Sodium alginate, Locust bean gum and Gelucire by melt granulation / covalent crosslinking method. By considering the percentage entrap performance, swelling index, in vitro buoyancy studies and their release data, the prepared IPN beads were optimized. Swelling of polymer started leading to continuous drug diffusion which continues for next 8 hrs. FTIR confirmed no drug polymer interaction and confirmed stability of drug within the IPN matrix beads. The crosslinking time and curing time of IPN beads affect the release of drug. The drug release kinetic confirmed first order and Higuchi model release kinetic as R2 value is close to one. In recent days, the semi IPN and cross-linked 3D IPN are also having numerous modern therapeutic applications in delivery of bioactive compounds on the form of hydrogel and nanoparticle based drug delivery system. Invention of IPN has reached strong long-term implications for the pharmaceutical industry
Keyword: Interpenetrating polymer network, Characterization, Semi-interpenetrating polymer network, Microspheres, Semi IPN and cross linked
DOI: https://doi.org/10.31838/ijpr/2021.13.02.022
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