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Fabrication and Characterization of Interpenetrating Polymer Network Matrices for Controlled Drug Delivery of Propranolol HCL Using Polymers Locust’s Bean Gum, Gelucire and Sodium Alginate
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| Author:
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MUNENDRA PAL, SWATI GAUTAM, SUKIRTI UPADHYAY, PRASHANT UPADHYAY
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| Abstract:
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Due to modification during its synthesis and enhancement that transforms new physicochemical and
mechanical properties within the formulation; the Interpenetrating polymer network (IPN) has shown great
interest in drug delivery. Based on literature survey, IPN research study was proposed which incorporates
their methods of preparation and characterization parameters such as U.V and FTIR studies and in vitro
release and animal studies using Wister rats. IPN beads are prepared for controlled release application using
Propranolol HCl (an antihypertensive drug), Sodium alginate, Locust bean gum and Gelucire by melt
granulation / covalent crosslinking method. By considering the percentage entrap performance, swelling index,
in vitro buoyancy studies and their release data, the prepared IPN beads were optimized. Swelling of polymer
started leading to continuous drug diffusion which continues for next 8 hrs. FTIR confirmed no drug polymer
interaction and confirmed stability of drug within the IPN matrix beads. The crosslinking time and curing time
of IPN beads affect the release of drug. The drug release kinetic confirmed first order and Higuchi model
release kinetic as R2 value is close to one. In recent days, the semi IPN and cross-linked 3D IPN are also
having numerous modern therapeutic applications in delivery of bioactive compounds on the form of hydrogel
and nanoparticle based drug delivery system. Invention of IPN has reached strong long-term implications for
the pharmaceutical industry
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| Keyword:
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Interpenetrating polymer network, Characterization, Semi-interpenetrating polymer network, Microspheres, Semi IPN and cross linked
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.022
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| Download:
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