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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Combination Use of Simvastatin and Metformin in Male Wistar Rats Following the Atherogenic Diet

Author: ABDURRAHMAN HASYMI, BATARI TODJA UMAR, RAHMAWATI MINHAJAT, ABDI DZUL IKRAM HASANUDDIN, AMELIA RUMI
Abstract: Atherosclerosis is a vascular disease that is the main cause of hypercholesterolemia. Statins are the most effective cholesterol-lowering drugs to date and metformin is also thought to have anti-atherosclerotic effects in addition to hypoglycemic effects. Statin-associated muscle symptoms (SAMS) are the effect of statin use up to 72%. To determine the effectiveness of the combination of simvastatin and metformin following the atherogenic diet in male Wistar rats. All rats were divided into five experimental groups. The negative control group (n = 5), the positive control group were given the atherogenic diet alone (n = 5), the P1 group were treated with simvastatin 20 mg / BW / day (n = 5), the P2 group were treated with simvastatin 40 mg / BW / day (n = 5), the P3 group were treated with simvastatin 40 mg / BW / day and added with metformin 2 g /BW. All drugs were given after a two-week atherogenic diet. All groups of rats were measured for body weight and length before the diet, in the second week, and after four weeks. Before the rats were sacrificed, blood is drawn to be measured for cholesterol, creatinine, ALT, and AST. After four weeks, the animals were sacrificed and collected for the aorta, liver, and muscles of the right leg organ. All the organs were then measured for their weight. In the measurement of the aortic organ weight (P = 0.041), there was a significant difference in the results in each treatment group, while the examination of the weight of the liver (P = 0.077) and leg muscles (P = 0.831) was not a significant difference in each group. On cholesterol measurement, there was a significant difference (P = 0.000) in each treatment group, while there was no significant difference in creatinine (P = 0.052), ALT (P = 0.059), and AST (P = 0.824) levels. On body weight (P = 0.003), Body Mass Index (BMI) (P = 0.002) and Lee index (P = 0.002) measurement, there were significant differences after the diet in each group, while body length (P = 0.249) was not significantly different after diet in each group. Conclusion We conclude, there is an association between simvastatin and metformin combination administration in male Wistar rats after being given an atherogenic diet.
Keyword: Atherogenic diet, atherosclerosis, hepatotoxic, metformin, simvastatin, statin-associated muscle symptoms
DOI: https://doi.org/10.31838/ijpr/2021.13.02.071
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