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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Investigation the Mechanism of Propyl-Cannabinol Allyldimethylsilyl Ether (PCAE) Efficiency in Inducing Program Cell Death in Treated MDA-MB-231 and LNCaP Cancer Cell Lines

Author: ASHWAQ SHAKIR AL-ABBOODI, WARQA, A MUHAMMED SHARIFF AL-SHEIKH
Abstract: Cytotoxicity launching by the novel phytochemicals is the target of most chemotherapeutic strategies. Propylcannabinol allyldimethylsilyl ether (PCAE) is a poor solubility compound naturally exists in the Rutaceae family one of the biggest medicinal plants in all over the world. In the current work, the molecular mechanism of (PCAE) as anticancer agent has investigated in several cancer cell lines. In this work MDA-MB-231 breast cancer and LNCaP prostate cancer cell lines were used. Several experiments such as: caspase 3 and 9, flow cytometer analysis and cell cycle arrest were performed during this work. The observed results were markedly appeared the immense efficiency of Propyl-cannabinol allyldimethylsilyl ether (PCAE) in inducing cell death at treated cells after 72 hours. Furthermore, there are a high percentage of the treated cells were situated at sub G0 phase which was indicating to high level of apoptotic cells. Otherwise, the mechanism that Propyl-cannabinol allyldimethylsilyl ether (PCAE) has followed was mitochondrial signaling pathway through inducing caspase-9. Therefore, this study suggests that Propyl-cannabinol allyldimethylsilyl ether (PCAE) can be a good candidate for developing anticancer agents.
Keyword: phytochemicals, cytotoxicity, apoptosis, cell cycle arrest and reactive oxygen species
DOI: https://doi.org/10.31838/ijpr/2021.13.02.117
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