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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Development of a New Methodology for Amlodipine Besylate (ADB) Determination Using Potassium Hexacyanoferrate (III) (PHF) as a Reagent and ISNAGFluorimeter Instrument via CFIA

Author: NAGHAM S.TURKEY AL AWADIE, GHUFRAN KHALID
Abstract: A new, simple, fast and sensitive method has been developed for the determination of Amlodipine besylate pure form and drugs (tablets) by continuous flow injection scatter light. The method was based on the reaction of the Amlodipine besylate with Potassium hexacyanoferrate (III) to form a precipitate, using homemade ISNAG- Fluorimeter. Optimum parameter have been studied to increase the sensitivity for developed method. The scatter plot range and the linear dynamic range for the instrument response versus Amlodipine besylate concentration was 0.1- 45 mmol/L while the L.O.D was 3.984µg /sample from the step wise dilution for the minimum concentration of lowest concentration in the scatter plot range of the calibration graph. The correlation coefficient (r) was 0.9849 and 0.9987 while percentage linearity (R2%) was 97% and 99.75 for the scatter plot range and the linear dynamic range(respectively). RSD% for the repeatability (n=8) was lower than 0.6% for the determination of Amlodipine besylate, with concentration of 3, 10 mmol/L respectively. The methods: developed method was applied successfully for the determination of Amlodipine besylate in pharmaceutical tablets. A comparison was made between the newly developed method with the classical method (Turbidemtric method and UV-spectrophotometer method) of analysis using the standard addition method via the use of paired t-test. It shows that there was no significant difference between the quoted values of each individual company with calculated t-value at 95% confidence interval from developed method.
Keyword: Amlodipine besylate, flow injection, scatter light, ISNAG-Fluorimeter instrument
DOI: https://doi.org/10.31838/ijpr/2021.13.02.091
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