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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Lagenaria Siceraria (family: Cucurbitaceae ): In Vivo Investigation of Antidiarrheal Activity in Different Doses of Ethanolic Peel & Petiole Parts in a Mice Model

Author: NISRAT JAHAN, DANIA AKTER
Abstract: Background: The aim of the experimental study was to explore antidiarrheal activity of ethanolic peel & petiole extract of L. siceraria (family: Cucurbitaceae) in a mice model. Study Design & purpose: 100 mg/kg and 200 mg/kg B.W ethanolic peel and petiole extracts were subjected to different swiss albino mice models to authenticate dose dependant antidiarrheal property of the plant. Methodology: In vivo antidiarrheal activity was performed by castor oil (0.5 ml /mice) induced method according to weight of wet stool and number of wet stool. 100 mg/kg & 200 mg/kg doses of ethanolic peel and petiole extract of L. siceraria was run in six groups mice model in comparison to standard Loperamide (5mg/kg B.W). Castor oil in saline solution was used as negative control group. Results: According to weight of wet stool ethanolic peel extract has confirmed highly significant antidiarrheal activity at 100 & 200 mg/kg B.W by inhibiting gastric motility by 63.41% (***P<0.001) & 90.24% (***P<0.001) accordingly whereas petiole part inhibited 80.48% (*P<0.05) & 85.37% (*P<0.05) diarrheal prevention was confirmed for people at same doses as compared to the 5mg/kg B.W Loperamide (92.68%; ***P<0.001). Based on no. of wet stool 100 & 200 mg/kg B.W ethanolic peel extract illustrated highly significant antidiarrheal activity by 68.89% (***P<0.001) & 86.67% (***P<0.001) accordingly whereas petiole inhibited gastric motility by 82.22% (*P<0.05) & 91.11% (*P<0.05) respectively in cmparison to Loperamide (95.56%; ***P<0.001). Conclusion: The attained results of the present study confirms antidiarrheal of the L. siceraria that could be a methodical basis for the expected & well-founded consumption of this plant as a curative agent for diarrhea
Keyword: L. siceraria, antidirrheal activity, pharmacological activity.
DOI: https://doi.org/10.31838/ijpr/2021.13.02.101
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