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Mesenchymal Stem Cells-Conditioned Medium (SECRETOME) in Skin Aging: A Systematic Review
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| Author:
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WINAWATI EKA PUTRI, ANANG ENDARYANTO, FEDIK ABDUL RANTAM, CITA ROSITA SIGIT PRAKOESWA
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| Abstract:
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Background: The skin aging is the most important factor that constitutes the general "well-being" and perception
of "health" in humans. The mesenchymal stem cells (MSCs) have a therapeutic effect on anti-apoptosis, angiogenic,
immunomodulatory and chemo-existing activity, especially in its treatment. However, the use of mesenchymal
stem cell-conditioned medium (MSC-CM) as skin aging therapy requires further investigation.
Methods: The systematic literature search have the following keywords; conditioned media or conditioned
medium or secretome as well as photoaging or skin aging. A total of 283 articles were reviewed from Pubmed,
Wiley Online Library, Science Direct and The Cochrane Library, and only 11 articles were relevant for this
systematic review.
Results: The results show that Secretome is promising in improving the skin aging process. However, due to the
high heterogeneity, a meta-analysis cannot be performed.
Conclusion: The use of secretome was promising in improving skin aging process, as shown by the available
preclinical studies. However, further clinical studies are needed to confirm the benefits and effects of secretome.
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| Keyword:
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mesenchymal stem cell, secretome, conditioned medium, skin aging.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.020
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| Download:
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