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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The Effect of Nutritional Supplement of Dried Figs on Renal Toxicity Induced by Ochratoxin (A) in Experimental Animals

Author: REEM ALAZRAGI
Abstract: Ochratoxin (A) is a fungal toxin that affects the kidneys, causing kidney failure. The kidney is the important target organ of this mycotoxin. This study aims to determine the efficiency of dietary fortification with dried figs as a rich source of antioxidants against renal toxicity induced by toxic fungicide. Forty white rats were used, divided into 4 groups: (1) the control group, (2) the group treated with ochratoxin (A), (3) a group fed by meals fortified with dried figs only, (4) a group that fed meals containing ochratoxin (A) and supported by dried figs. Some measurements were made that included renal function, antioxidant enzymes in the renal tissue, DNA fragmentation test, and histopathological kidney dissection test. A significant decrease in body weight, kidney weight, and relative weight was observed in the group treated with ochratoxin (A), as well as an increase in the level of creatinine, urea, sodium and potassium in the blood. Histopathological and histopathological changes appeared as the renal tissue lost its normal shape with the appearance of DNA cracking. As for the group that fed only the dried figs, their results were close to the control group, whereas in the group fed on the dried figs with the ochratoxin (a), the severity of the pathological changes, whether related to renal function or enzymatic stress enzymes in the renal tissue as well as the pathological dissection of the kidneys, decreased. And DNA cracking. The results indicate that the ochratoxin (A) causes pathological changes in the kidney tissue that may lead to kidney failure, and that the nutritional support of dried figs in the meals containing the ochratoxin (A) has a protective effect, as the damage caused by the toxicity of the ochratoxin (A) on the kidney tissue has been reduced.
Keyword: fig, ochratoxin (A), kidney and renal toxicity
DOI: https://doi.org/10.31838/ijpr/2021.13.02.111
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