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Formulation and Characterization of Piroxicam Nano Crystalline Suspension and Spray Dried Powders
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| Author:
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, SHRAVANTH S H, SHARADHA M, C.SAI KISHAN, SIDDARAMAIAH, D V GOWDA
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| Abstract:
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The research study was to develop and evaluate the Nano crystalline suspension of piroxicam that improves
the dissolution rate. Piroxicam belongs to class II of BCS classification which is poorly water soluble. To
improve the solubility the drug is converted in to Nano crystalline suspension form. The milling process
consists of milling media and is allowed to move through the dispersion media by the planetary milling. The
suspension obtained by both the process was measured by particle size using a zetasizer. The evaluation
parameters like DSC, PXRD, HPLC, and in-vitro dissolution study was carried to know the interaction
between the drug and excipient the drug released to the nano suspension is noted. The process followed of
spraying is down streaming spray drying. The drug and stabilizer was added in an optimized form to get the
physically stable suspension to get the desired particle size.
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| Keyword:
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Piroxicam, Nano crystalline suspension, spray granulation.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.024
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| Download:
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