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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Histopathological and Enzymatic Changes in Male Mice Liver Induced by CeO2 nanoparticle

Author: SAMAHER SABRY HAMMID, SAMI JEBER AL-MALIKI, ALI A.A.AL-ALI
Abstract: This study conducted to assess the effects cerium oxide nanoparticles on liver enzymes and hepatocellular changes due to I/P administration of cerium oxide nanoparticles in male mice. White laboratory mice Mus muscular L. strain BALB / C were used. The results of the current study showed a significant increase in the level of ALT and AST enzymes for male laboratory mice injected with cerium oxide in the two doses and for two periods compared with the control group. Microscopic examination of histological sections of the liver showed pathological changes after injection of mice with cerium oxide in both low and high doses included dilatation in the central vein , congestion , infiltration of inflammatory, hyperplasia of hepatic cells, multinucleated cells and necrosis.
Keyword: Cerium oxide, liver enzymes, histopathology.
DOI: https://doi.org/10.31838/ijpr/2021.13.02.064
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