IJPR  articles are Indexed in SCOPUS (2010 - 2021)Click Here     *Five Years Citation in Google scholar (2016 - 2020) is. 1451*        Now IJPR is Q2 in SJR Ranking     Scopus Coverage of IJPR (2010-2021 Issue 1)            

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Formulation, Optimization and Evaluation of Gellan Gum Based in Situ Nasal Gel of Selegiline for Depressive Disorders

Author: SHIV KUMAR SRIVASTAVA, MAHESH PRASAD, ANTESH KUMAR JHA
Abstract: In situ gel are gelling system in which polymer dispersion or solution is in liquid state, but of the influence of various stimuli like temperature, pH causes conversion of liquid state to semisolid (gel) state. In present study gellan gum is used as ion induced polymer which converted into a gel state due to presence of cation in nasal mucosa. HPMC is used as copolymer for increasing consistency of sol which increase residence of sol in nasal cavity and also prevent water loss after gelation. Selegiline is a selective monoamine oxidase-A & B inhibitor (dose dependent) which is majorly used as an antiparkinson drug but also approved as an antidepressant drug in USA. Hence, in our present study gellan gum based in situ gel of selegiline was developed and evaluated for various physiochemical and biological parameters for its efficacy against depressive disorders. Various parameters like Gelling time, PH, Mucoadhesive strength, Gel strength, Drug content, In vitro, Ex vivo release and In vivo release were studies. Gelling time, PH, Viscosity (sol and gel both), Mucoadhesive strength, Gel strength, Drug content, In vitro release study of an optimized formulation batch revealed 16.7±0.6 second, 6.5±0.1, 142.3±1.2 CP, 1427.6±1.2 CP, 99.73±0.2%, 3518.10±0.96 dyne/cm2, 41.3±0.6 seconds respectively. Histological evaluation of nasal mucosa of sheep after application of an optimized batch formulation showed no significant change in structure of neither mucosal layer nor necrosis. In vivo study of prepared optimized in situ gel showed more efficacies comparable to marketed oral tablet of selegiline
Keyword: In situ gel; gellan gum; selegiline; HPMC; mucoadhesive strength; gel strength
DOI: https://doi.org/10.31838/ijpr/2021.13.02.046
Download: Request For Article
 




ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free