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Formulation, Optimization and Evaluation of Gellan Gum Based in Situ Nasal Gel of Selegiline for Depressive Disorders
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| Author:
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SHIV KUMAR SRIVASTAVA, MAHESH PRASAD, ANTESH KUMAR JHA
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| Abstract:
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In situ gel are gelling system in which polymer dispersion or solution is in liquid state, but of the influence of
various stimuli like temperature, pH causes conversion of liquid state to semisolid (gel) state. In present study
gellan gum is used as ion induced polymer which converted into a gel state due to presence of cation in nasal
mucosa. HPMC is used as copolymer for increasing consistency of sol which increase residence of sol in nasal
cavity and also prevent water loss after gelation. Selegiline is a selective monoamine oxidase-A & B inhibitor
(dose dependent) which is majorly used as an antiparkinson drug but also approved as an antidepressant drug in
USA. Hence, in our present study gellan gum based in situ gel of selegiline was developed and evaluated for
various physiochemical and biological parameters for its efficacy against depressive disorders. Various parameters
like Gelling time, PH, Mucoadhesive strength, Gel strength, Drug content, In vitro, Ex vivo release and In vivo
release were studies. Gelling time, PH, Viscosity (sol and gel both), Mucoadhesive strength, Gel strength, Drug
content, In vitro release study of an optimized formulation batch revealed 16.7±0.6 second, 6.5±0.1, 142.3±1.2
CP, 1427.6±1.2 CP, 99.73±0.2%, 3518.10±0.96 dyne/cm2, 41.3±0.6 seconds respectively. Histological evaluation
of nasal mucosa of sheep after application of an optimized batch formulation showed no significant change in
structure of neither mucosal layer nor necrosis. In vivo study of prepared optimized in situ gel showed more
efficacies comparable to marketed oral tablet of selegiline
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| Keyword:
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In situ gel; gellan gum; selegiline; HPMC; mucoadhesive strength; gel strength
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.046
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| Download:
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