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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Design and Development of Cetirizine HCL Oral Disintegrating Mini-Tablet for to Enhances Patient Compliance

Author: KOWSALYA N, N GOPINATH, KALAISELVI R, C.SAI KISHAN, SHARADHA M, MEENAKSHI S, SIDDARAMAIAH, D.V.GOWDA
Abstract: AIM: The main aim of the research study was to formulate and evaluate the oral disintegrating mini-tablets (ODMTs) containing cetirizine HCl prepared by direct compression method. Method: In my research work super disintegrating agent such as sodium starch glycolate and PVP are used and the effectiveness of these disintegrating agents are compared along with the other excipients Based on the concentration of disintegrating agents such as sodium starch glycolate and PVP the different formulations are prepared using direct compression method. The prepared tablets were evaluated for drug and excipient interactions using FTIR. The pre-formulation studies like tap density, bulk density, carr’s index, Hausner's ratio, and post-compression studies like tablet thickness, weight variation, hardness, friability, disintegration and in-vitro dissolution studies were performed. FTIR and DSC studies showed that no chemical interactions between the drug and excipients used. Micromeritic properties of formulation, K3 exhibits better flow property. Result: Formulation K3 showed better thickness (3.76mm), weight variation, hardness (4.1 kg/cm2), friability (0.7%), drug content (98.4), disintegration time(32 secs), drug release(96.3%) compared to other formulations. Conclusion: Hence,it as concluded that formulation K3 consist of 7% sodium starch glycolate suitable to deliver CTZ HCl in the form of Oral disintegrating mini-tablet for patient compliance.
Keyword: Oral disintegrating mini-tablet (ODMT), Cetirizine HCl, Sodium starch glycolate, Crospovidone.
DOI: https://doi.org/10.31838/ijpr/2021.13.02.059
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