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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Impact Of Morin Hydrate As A Potential Therapeutic Agent In Attenuation Titanium Dioxide Nanoparticles Neurotoxicity In Rats

Author: KHADIJAH E.MANSOUR, IMAN A.SHARAF, NADIA A.ABDULMAJED, HANAN S.ALNAHDI
Abstract: Titanium dioxide (TiO2) particles belong to the most widely manufactured nanoparticles (NPs) on a global scale because of their photocatalytic properties and the related surface effects. The present study focused on the biochemical, histological and genotoxic effect of TiO2 NPs on rat’s brain and explore the prophylactic effect of Morin hydrate extract. The study included sixty male albino rats weighing 180-200 g, divided into six groups (n=10) treated by single dose orally for 14 constitutive days. Group I control group. Group II received Morin hydrate (50mg/kg b.wt). Group III received TiO2 NPs (50 mg/kg b.wt). Group IV received TiO2 NPs (100 mg/kg b.wt). Group V received Morin hydrate and TiO2 NPs as in group II and III. Group VI received Morin hydrate and TiO2 NPs as in group II and IV. TiO2 concentration, biomarkers of oxidative stress, inflammatory mediators, acetylcholine esterase and Presenilin 1(Relative mRNA expression) had been measured in brain tissues. The results showed significant increase in MDA, IL-6, NF-kB, PSEN1 and significant decrease of SOD, CAT, AChE in brain tissues were noticed in response to TiO2 intoxication with different doses. Co-administration with Morin hydrate attenuated all the parameters near the normal levels. Furthermore, histopathological examination of animal treated with TiO2 exhibited neuronal degeneration, apoptosis and neuronal vacuolation. The study indicated that neuro-toxicological effect of TiO2 was dose dependent and supported the anti-inflammatory and the ROS scavenger activity of Morin which can justify many of the observed beneficial pharmacological activities.
Keyword: Morin hydrate, Neuroprotective, TiO2 NPs, Neurotoxicity.
DOI: https://doi.org/10.31838/ijpr/2021.13.02.082
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