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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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In Vitro study on Antidiabetic Potential of Crude Plant Extracts by Attenuating Oxidative- Stress and Advanced Glycation End-Product

Author: MYA THIDA, CHAN MYAE NYEIN, KHIN NYEIN CHAN, MYINT THET NEW, SHUN LAI EI, KHIN MAR MYA
Abstract: Aims: This study aimed to highlight the potency of eight crude plant extracts in antioxidants, phenolic content, and AGEs inhibition by using different parameters such as DPPH, ferric reducing powers, nitric oxide, superoxide, Folin-Ciocalteu, and BSA-glucose antiglycation methods. Results: Tested extracts exhibited free radical scavenging activity, oxidant reducing power, and the high total phenolic content. Among them, Butea monosperma Roxb. (B. monosperma) showed the best anti-oxidative effects on free radicals such as DPPH, ferric chloride, nitric oxide, and superoxide as well as the highest amount of total phenolic content. B. monosperma exhibited the highest antioxidant activity for DPPH, nitric oxide and superoxide assays, (IC50 values (mg/ml) of 0.03±0.003, 0.02±0.001, and 0.04±0.001), respectively. B. monosperma also showed the highest amount of reducing capacity with a higher absorbance value. Besides, B. monosperma possessed the high total phenolic content of 449.85± 9.3 (mg GAE/g of extract). Moreover, B. monosperma had a significant antiglycation activity with the IC50 value of 0.04±0.002 mg/ml, compared with the standard drug rutin 0.041±0.006 mg/ml. Conclusion: Therefore, this study suggested that B. monosperma had high antiglycation ability to attenuate the AGEs formation with antioxidant capacity, which could be considered as a glycation inhibitor for therapeutic purposes in diabetes mellitus.
Keyword: reactive oxygen species (ROS), Advance Glycation End products (AGEs), diabetes mellitus, antioxidant, antiglycation
DOI: https://doi.org/10.31838/ijpr/2021.13.02.063
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