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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Therapeutic Anti-metabolic Cytotoxic Drug Monitoring: Present State and Future Prospects

Author: , YADAGIRI PHALGUNAA, ABHISEK PALB
Abstract: Therapeutic drug Monitoring isn't routinely used for antineoplastic agents. There are numerous reasons, however one fundamental downside is that the lack of connected healing awareness levels. Combination therapy makes it difficult to determine healing standards for character capsules, the unattached drug awareness-effect court would not be almost like that after the drug is used during a drug combination. Nevertheless, methotrexate is the best agent that is immediately pursued in maximum remedy centres. An additional factor, especially in the antimetabolite remedy, is that pharmacogenetic enzyme lifestyles play an essential part in drug metabolic process. Medication monitoring may want to include phenotypic enzyme sporting or genotype assays further to, or as an alternative to, the additional traditional size of drug or drug metabolites determined. Lack of thiopurine methyltransferase (TPMT) causes life-threatening mercaptopurine myelotoxicity in a purposeful pastime. Very low passing time with dihydropyrimidine dehydrogenase (DPD) decreases fluorouracil breakdown, causing excessive cytotoxicity. The bioavailability, clinical pharmacokinetics, genotoxicity and efficacy of their substrate drugs may be influenced by these pharmacogenetic enzymes.
Keyword: Cytotoxic drugs, Fluorouracil, Capecitabine, Methotrexate
DOI: https://doi.org/10.31838/ijpr/2021.13.02.048
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