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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of long term use of PPI on high sensitive C-reactive protein, pilot study

Author: NOOR KADHIM MOHAMMED-JAWAD
Abstract: Background: proton pump inhibitors (PPIs) one of commonly used medications due to their availability as OTC medications however there are many concerns about the safety of their long-term use. This pilot study aimed to measure the level of high sensitive C-reactive protein level as a risk factor marker for cardiovascular disease in patient use PPIs for long time. Method: Twenty-four adult patients were incorporated in the study. All patients were taking PPI for at least one year. Those patients considered group A. In addition apparently healthy control group considered as group B. Patient information and blood sample were taken from all participants and the level of hs-CRP were measured. Results: the age of patients were forty years old, most of them were females. The level of hs-CRP were classified into high, moderate and low. Patients who use ppi for long time have higher level of hs-CRP, however there is non-significant differences hs-CRP were found between group A and group B. Conclusion: The long-term use of PPIs may cause an increase in the level of hs-CRP level. The long term use of PPIs may not be without health concerns especially on cardiovascular system. Further large-scale study required to investigate these effects.
Keyword: proton pump inhibitors, Long-term use, High sensitive-CRP
DOI: https://doi.org/10.31838/ijpr/2021.13.02.045
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