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Development and Evaluation of Fast Dispersible and Slow Releasing Indomethacin Tablets to Improve Patient Compliance.
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| Author:
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YASHAS M S, AFRASIM MOIN, MAITHRI SHANBHOGUE H, SHAILESH T, AMIT B PATIL, SIDDARAMAIAH, D V GOWDA
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| Abstract:
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Aim: The aim of the present study was to develop fast dispersible and slow releasing Indomethacin (IM) tablets to improve patient compliance.
Methods: Fast dispersible and slow releasing Indomethacin tablets by wet granulation method.
Results: The drug was mixed with Cocoa butter, a saturated lecithin, to avoid bitter taste and adverse effects of the medication. FTIR and DSC studies confirm the compatibility between drug and excipient. Micrometric properties of the prepared granules were well within the limit confirmed by free flowing. The granules were then coated with film forming compounds Eudragit RD 100. Coated granules are then mixed with a sweetener, aspartame, mannitol as a diluent and Kollidon CL as a superdisintegrant was introduced and compressed under low compressive force. Dissolution profile proposed that the combined action of hydrophobic lecithin and the coating prolongs the release of drug from tablets when it becomes free or in the for simple granules. With the correct combination of excipients, orally disintegrating tablets could be achieved with simple and traditional techniques.
Conclusion: Fast dispersible and slow dissolving tablet can be used for paediatric and geriatric patients and can be used as effective treatment during emergency pain.
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| Keyword:
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Indomethacin; Coated granules; orally disintegrating; Patient compliance.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.016
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| Download:
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