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Evaluation of Involvement of Adrenergic Receptor Modulator in Experimental Diabetes Induced Vascular Endothelial Dysfunction and Related Dementia in Rats.
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| Author:
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B.M.SHARMA , BHUPESH SHARMA
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| Abstract:
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Objective: Vascular Dementia (VaD) is associated with metabolic conditions. Diabetes is a risk factor for the development of VaD. This study investigates the efficacy of nicergoline in pancreatectomy (PaD) induced diabetes induced vascular endothelium dysfunction and related dementia.
Methods: PaD has induced hyperglycemia in Albino Wistar rats (male, 230-250g). Morris water maze (MWM) and attentional set-shifting tests (ASST) were used to assess spatial learning, memory, reversal learning, and executive functioning in animals. Bodyweight, serum glucose levels, serum nitrite/nitrate levels, vascular endothelial function, aortic superoxide anion, brains’ oxidative markers (thiobarbituric acid reactive species-TBARS, reduced glutathione-GSH, superoxide dismutase-SOD, and catalase-CAT), inflammatory markers (myeloperoxidase-MPO), calcium levels, acetylcholinesterase activity-and AChE activity were also assessed. Nicergoline (5 mg/kg or 10 mg/kg; p.o.) was used as the treatment drugs. Donepezil (0.5mgkg-1) was used as a positive control.
Results: PaD induced diabetes caused reduction in learning, memory, reversal learning, executive functioning, impairment in endothelial function, increase in mean arterial blood pressure, brains’ oxidative stress, inflammation, calcium levels, and AChE-activity. Administration of nicergoline significantly attenuated the Pad induced diabetes-induced impairments in the behavioral, endothelial, and biochemical parameters.
Conclusion: PaD induced diabetes produced impairment in behavioral, endothelial, and biochemical parameters which were attenuated by the administration of nicergoline. Therefore, nicergoline may be studied further for the assessment of its full potential in PaD induced diabetes-induced VaD.
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| Keyword:
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Pancreatectomy, Endothelial dysfunction, Vascular Dementia, Nicergoline
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.650
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| Download:
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