|
Design, Development And Evaluation Of Antidiabetc Matrix Tablets Using Natural And Synthetic Polymers
|
|
| Author:
|
HIMABINDU PEDDAPALLI, MADHURIKA SIRIGADI , MD FAHEEMUDDIN, RAMKOTESWARA RAO AMARA, ANANDA KUMAR CHETTUPALLI
|
| Abstract:
|
This research was conducted to create anti-diabetic tablets from chemicals that have been compressed using a mechanized direct compression process. The tablets were chemically tested and their release in-vitro experiments were also performed. Different batches of hydrophilic polymer content and Karaya Gum formed tablets with uniform hardness (3-4mm) and thickness (2-3mm). The friability (0.29-0.51%), weight variance (1.18-2.54%), and Substance quality (95.40-98.86%) of multiple tablets was identified inside the limits prescribed. The swelling degree was associated with polymer standard irrespective of whether it was a diluent or polymer. The release profile showed that increasing the concentration of the copolymer had retarded the release of Gliclazide irrespective of the kind of polymer used. Both drug release from all matrix tablets is caused by polymer swelling and relaxation with ratio lies 0.45 to 0.89. Therefore, the FTIR study showed no chemical reactions between medication and polymers used. According to the samples, the sample was found to be hard and the overall substance concentration was over 98 percent at the end of the study. Among the formulations in which F2 HPMCK100M hydrochloride tablets have the best continuous release of glipizide. Using triggered epilepsy rats to evaluate the time course of the drug.
|
| Keyword:
|
Matrix tablets; Sustained release; Gliclazide;Direct compression; In- vitro release.
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2021.13.01.599
|
| Download:
|
Request For Article
|
|
|