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Development and Evaluation of Controlled Release
Badam Gum Spherules Containing Aceclofenac
Sodium and Paracetamol to Improve Patient
Compliance
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| Author:
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SURAJ S, AMIT B PATIL, AFRASIM MOIN, SIDDARAMAIAH, MEENAKSHI S, D V GOWDA
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| Abstract:
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Aim: The aim of the present study was to develop controlled released badam gum (BG) spherules containing
Aceclofenac sodium (ACF) and Paracetamol (PCT) to improve patient compliance.
Methods: Controlled released BG spherules containing ACF and PCT prepared by Hot melt extrusion
method.
Results/Outcome: Fourier Transform Infrared (FTIR) Spectroscopic Analysis and Differential Scanning
Calorimetry (DSC) studies confirmed the compatibility between drug and excipient. SEM studies revealed the
prepared spherules are free from surface dents. Micromeritic properties of the prepared spherules were well
within the limit confirmed by free-flowing. Prepared spherules showed 83% drug loading and drug release
behavior was influenced by erosion of the spherules followed diffusion-based transport. The solubility of the
drug revealed the influence on the erosion of the matrix. X-ray diffraction (XRD) is used to determine the
crystalline state of the extruded matrices and interaction between matrix and incorporated drugs.
Conclusion: In conclusion, high mechanical strength of the spherules is a clear advantage compared to
lyophilized formulations and can improve patient compliance.
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| Keyword:
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Aceclofenac sodium, Paracetamol, Badam Gum, Spherules, Patient compliance
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.667
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| Download:
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