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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Application of Statistical Tools for Optimization of Itraconazole Microemulsion

Author: ANAND S, K.R.KUMAR
Abstract: The goal of this analysis is to optimize the microemulsion loaded with Itraconazole by phase titration. Selections of content attributes for microemulsion formulation are selected by constructing a pseudo-ternary phase diagram of different oils and surfactant concentrations. Optimization of the formulation technique of Itraconazole microemulsion was carried out with 2 centre points by Central Composite Configuration using selected critical material attributes such as different oils , surfactants concentration and evaluated for its effect on critical quality attributes such as PS nm, ZP mV, EE percent, PI, RI, percent Drug Content and Self Emulsification Time (sec). The Itraconazole Microemulsion chosen from this optimization research results is subject to calculation for its in vitro drug release tests. The formulation of IM9 showed promising results in tests of particle size, poly dispersibility index, entrapment performance and drug release. All of the above data indicates that IM9 was chosen as an imp
Keyword: Itraconazole, Central composite Design, pseudo ternary phase diagram, Zeta potential, Particle size.
DOI: https://doi.org/10.31838/ijpr/2021.13.02.039
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