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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Analytical Method Development and Validation of Macitentan by RP-HPLC Method

Author: CHABALA OBIREDDY, CHANDAN R S, BARATH M, ANAND KUMAR TENGLI
Abstract: Macitentan is an endothelin receptor antagonist authorized for Pulmonary arterial hypertension therapy. Endothelin is a highly active agent constricting blood vessels that is naturally produced by endothelial cells. By inhibiting the binding of ET-1 to ET receptors, Macitentan inhibits the ET1-dependent Which increase the intracellular calcium. Therefore, an accurate, fast, simple and cost-effective RP-HPLC technique for detecting Macitentan was developed. The RP-HPLC method is developed by using ACN and Acetate buffer 80:20 v/v as MP, the Flow rate is maintained at 1.5 mL/minute. Detection of Macitentan was performed by using UV detector at 263nm. By this proposed method RT of Macitentan was identified at 3.1 min. The method was validated concerning system suitability, linearity, accuracy, precision, robustness and ruggedness according to ICH guidelines
Keyword: UV detector, RP-HPLC method, Macitentan, ICH guidelines.
DOI: https://doi.org/10.31838/ijpr/2021.13.02.061
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