IJPR  articles are Indexed in SCOPUS (2010 - 2021)Click Here     *Five Years Citation in Google scholar (2016 - 2020) is. 1451*        Now IJPR is Q2 in SJR Ranking     Scopus Coverage of IJPR (2010-2021 Issue 1)          Journal is Currently Not Indexed in Scopus as on february 2021 list provided by scopus

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
No Data found.
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
The Carbofuran Exposure During Lactation Period in Reducing the Motoric Reflexes and Memory in Infant Mice (Mus musculus)

Author: EPY MUHAMMAD LUQMAN, WIDJIATI, EKA PRAMYRTHA HESTIANAH, GRACIA ANGELINA HENDARTI, LITA RAKHMA YUSTINASARI, VISKI FITRI HENDRAWAN
Abstract: This study aimed to determine the function of motoric reflexes and memory as a result of the necrosis of neuron cells in the cerebellum of infant mice (Mus musculus) from their carbofuran exposed mothers during lactation periods. The decreased motoric reflexes as an indicator of the reduced memory ability and concentration ability in infant mice. This experimental laboratory study used 36 mice and carbofuran injected using gavage method with the fraction of LD50 in mother mice in the dose of 5 mg/kg body weight (BW). The mother mice were exposed with carbofuran during lactation period from Day 0 to Day 9 and the 10-days-old infant mice were then terminated for microscopic examination by counting the necrosis of neuron cell by applying HE staining and the motoric-reflex function tests (neurobehavioral test) on the 10-days-old infant mice which included: surface righting reflexes, swimming and a memory test employing an Eight-arm radial maze at 20 days- old. The calculation results were analyzed using the Kruskal-Wallis test and the Mann Whitney test. The results of this study showed a significant increase in the necrosis of neuron cell, a fundamental decreased motoric reflex in infant mice in these activities; such as surface righting reflex and swimming ability (the head angle position and swimming direction) and eight-arm radial maze memory test. Conclusion: in sum, the exposure of carbofuran in the mother mice during lactation period causes the increase in necrosis of neuron cell, the decrease of motoric reflexes and the memory ability for infant mice.
Keyword: Carbofuran, neuron cells, lactation, motoric reflexes, memory
DOI: https://doi.org/10.31838/ijpr/2021.13.01.029
Download: Request For Article
 




ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free