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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Investigation of eNOS gene intron 4 A/B VNTR and ACE gene I/D Polymorphism in Autosomal Dominant Polycystic Kidney Disease Cases

Author: GHUFRAN S.SALIH, KHAMAEL HASAN OBAID, ZAHRAA A.ALTHABET, TAHA H.ALNASRAWI
Abstract: Aim: This research aimed to investigate whether endothelial nitric oxide synthase of eNOS intron 4 polymorphism and ACE gene I/D polymorphism have a role in the enhancement of the progressive of ADPKD with regards to hypertension. Materials and Methods: The research was executed on 50 members with ADPKD presented in some dialysis centers in Baghdad city/ Iraq and 50 similar age healthy controls individuals. The eNOS gene polymorphisms (intron 4 VNTR 4a/b) and ACE gene polymorphism were determined by the polymerase chain reaction method. Results: In the current research shows the ACE gene polymorphism is independent factors for hypertension in the ADPKD patients with high significant factors (DD p<0.001); also for eNOS intron 4 gene polymorphisms were expressively different between ADPKD patients whose with hypertensive and whose with normotensive (4a p<0.001). Conclusion: This research investigated that ACE and eNOS gene polymorphisms are associated with ADPKD patients concerning hypertension. For future studies, it must investigate other gene polymorphisms that responsible for hypertension to reveal the relation effect on the progressive of ADPKD.
Keyword: eNOS gene, ACE gene, ADPKD, Hyper ten
DOI: https://doi.org/10.31838/ijpr/2021.13.02.029
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