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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Ethanol Extract of Cordia myxa L Fruit Increase Expression of Antioxidant Enzymes and Tumor Suppressor PTEN Genes in MCF-7 Breast Cancer Cells

Author: ZAINAB TUAMA AL-DALLEE, KAWTHER TUMA KHALAF, ZEENAH WEHEED ATWAN
Abstract: In the current study, the cytotoxicity of an ethanol extract from the fruits of Cordia myxa was studied, in addition to the effect of the extract on the gene expression of antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) in human breast adenocarcinoma cells (MCF7). The study also included the effectiveness of the extract to stimulate tumor phosphatase and tensin homolog (PTEN) gene expression. The results proved that treating MCF7 cells with C. myxa ethanol extract led to a significant decrease in cell vitality (up to 70%), and the cells treated with ethanol extract showed higher expression activity of all antioxidant enzymes with real-time PCR results at a concentration of 455.8 µg / mL, in this way, it overpowered the cells exposed to H2O2 (200 µM) and not treated with the plant extract that showed reductions in the expression of enzymes SOD, GPx and CAT., we demonstrated the activity of C. myxa extract to increase PTEN expression in MCF7 cells approximately 5 to 6 times compared to cells that were not treated. Results of our study indicated that C. myxa Fruit is useful as a curative agent in prevention diseases resulting from oxidative exertion.
Keyword: antioxidant enzymes, PTEN gene, Cordia myxa,
DOI: https://doi.org/10.31838/ijpr/2021.13.02.006
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