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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Evaluation of Antiallergic Activity of Celosia Argentea L. Seeds

Author: R.N.KALE , R.Y.PATIL
Abstract: Introduction: Celosia argentea (family- amaranthaceae) is mainly used in traditional medicine. It is the common weed occurring throughout India. It has hundreds of tiny flowers and black coloured seeds. Objectives: Objectives of the study was to assess the possible antiallergic activity of Celosia argentea L seeds. Methods: Extract of Celosia argentea L. seeds was prepared in soxhlet apparatus using methanol as a solvent. Preliminary screening for various phytochemical in the prepared extract was studied using chemical tests. Antiallergic activity of the prepared extract was evaluated by using animal models, catalepsy induced by clonidine in mice, leukocytosis and eosinophilia induced by milk in mice and passive cutaneous anaphylaxis in rats. Results: Subcutaneous administration of clonidine created catalepsy in all mice. In a control group, catalepsy was noticed for maximum duration of 90 minutes after the administration of clonidine. The prepared test extract indicated significant (p?0.05) hindrance of catalepsy created by clonidine. Administration of milk (4mg/kg, s.c) indicated significant increase in leucocytes and eosinophil count after 24 hrs of administration. Test extract demonstrated significant restraint (p?0.05) of milk instigated leukocytosis and eosinophilia. Sodium chromoglycate and prepared test extract demonstrated significant (P ?0.001) inhibition in zone of Evans blue color spillage as compared to control group. Sodium chromoglycate and test extract demonstrated 84.77% and 39.74% inhibition of area of Evans blue color spillage. Conclusion: The outcome proposes that the Celosia argentea seed extract may have the potential therapeutic value in the treatment of allergic diseases.
Keyword: Celosia argentea, Anti-allergic, Catalepsy.
DOI: https://doi.org/10.31838/ijpr/2021.13.02.001
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