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Anticonvulsant activity of alcoholic leaf extract of Centella asiatica in rats
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| Author:
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M S UMAMAGESWARI, V RHEVANTH, T M KARTHIKEYAN
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| Abstract:
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Objective: Evaluation of anticonvulsant activity of alcoholic extract of dried leaves of Centella asiatica in experimentally induced convulsion
Methods: Experimentally convulsions were induced by Maximal electro shock (MES) and Pentylenetetrazol (PTZ). Alcoholic leaf extract of Centella asiatica was used in the dose of 400mg/kg orally to check its anticonvulsant activity. Phenytoin 25mg/kg was used as a standard drug for MES induced seizures to prevent generalised tonic clonic seizures and Diazepam 4mg/kg was used as the standard drug in PTZ induced convulsion to prevent absence seizures.
Results: Alcoholic extract of leaves of Centella asiatica delayed the onset of tonic hind limb extension, decreased the duration of tonic hind limb extension and decreased the duration of post ictal depression significantly in MES induced seizures. In PTZ induced seizures alcoholic leaf extract of Centella asiatica significantly decreased the latency period. It prevented convulsion in 50% of animals.
Conclusion: Alcoholic extract of Centella asiatica had potent anti-convulsant activity in MES and PTZ induced seizures.
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| Keyword:
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Anti-convulsant activity, Centella asiatica, Maximal electroshock seizures, Pentylenetetrazole.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.379
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| Download:
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