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Enrichment of Gut Ecosystem by Daily Supplementation of Selective Probiotic Strains and Probiotic Complex in Dysbiosis Condition of Autism
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| Author:
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K.SUNAND , G.KRISHNA MOHAN, VASUDHA BAKSHI
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| Abstract:
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Context: Probiotics are functional foods involved in gut health support and establishment of Gut-Brain-Axis, adequate supplementation of probiotics needed in autism.
Background: Gut microbial ecosystem very essential for the functioning of gut and establishment of proper gut-brain-axis. This article aims to evaluate the effect of selected probiotic strains supplementation and probiotic complex on the microbiota colonization in the gut and recognize its implication in autism. Dysbiosis is important comorbid condition of autism. Daily administration of probiotics can impact microbiota composition and intestinal performance.
Method: On embryonic day 12, valproic acid was administered at a dosage 400 mg/kg, i.p. the born rats exhibited autistic features, treatment duration for this study is postnatal day (PND 8-50) with the Selective probiotic strains and probiotic complex with a dosage Not Less Than (NLT) 1 Billion (CFU) Colony Forming Units CFU/ml, p. o.
Results: Selective probiotic strains and Probiotic complex treatment significantly ameliorated in behaviors (p<0.001) Negative geotaxis (15.60±0.67 vs 1.80±0.20), T-maze (0.714±0.184 vs 4.00±0.00), Morris water maze (111.8±7.81 vs 12.66±1.43), Social interaction (6.83±0.74 vs 23.33±0.66), Repetitive Behaviour (7.40±0.67 vs 13.80±0.86), increased biochemical were significantly attenuated IL-6 (47.58±1.07 vs 27.45±0.57), TNF-a (134.61±1.85 vs 100.1±1.56), BDNF (59.74±1.07 vs 45.57±1.06), 5-HT (26.84±1.31 vs 8.39±1.74), AchE (6.40±0.36 vs 1.64± 0.12) along with restoration of areas of cerebellum Molecular layer and Granular layer become normal.
Conclusion: Probiotics supplementation enriches the microbial diversity and colonization of useful microbiota that can alter the Dysbiosis and improves Gut-Brain-Axis.
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| Keyword:
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Autism; Gut microbiota; Probiotic strains; Probiotic Complex; Dysbiosis; Valproic acid.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.615
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| Download:
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