|
Trends in Minimum Inhibitory Concentrations of Linezolid and Tigecycline on Various Clinical Isolates of Methicillin-Resistant Staphylococcus aureus
|
|
| Author:
|
AYESHA FIRDOSE, ASHWINI HEGDE, SEVITHA BHAT, ARCHANA BHAT, RADHAKRISHNA M
|
| Abstract:
|
Linezolid and Tigecycline have gained applicability in the past few years as the treatment modality for MRSA (Methicillin-resistant Staphylococcus aureus) infections as the options are limited. Linezolid has a spectrum limited to gram-positive bacteria. Tigecycline has a broad-spectrum activity. Minimum Inhibitory Concentrations (MICs) were determined by agar dilution and E-test methods, according to the Clinical and Laboratory Standards Institute (CLSI) and the Food and Drug Administration (FDA) criteria. Linezolid demonstrated high activity, and 99% of the strains showed susceptibility, and 98% of the strains were susceptible to tigecycline. Cefoxitin resistance was seen in 4% isolates even though they failed to produce a mecA gene band by PCR (Polymerase Chain Reaction). The present study results indicated that the new treatment methods for MRSA infections using linezolid and tigecycline are excellent. However, the MICs of these antibiotics are closer to the cut-off range and may become resistant to MRSA.
|
| Keyword:
|
Linezolid, Tigecycline, MIC, MRSA.
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2021.13.01.656
|
| Download:
|
Request For Article
|
|
|