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The Clinical Cruciality of Resistin in the Emanation of Polycystic Ovary Syndrome in Female Individuals and Its Prediction
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| Author:
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, HAAEL SUBHI ABBAS
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| Abstract:
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Background and Aim: The adipokine resistin, with its novelty, has been recognized to be associated with the
emergence of insulin resistance (IR) and obesity, the two co-morbidities related to polycystic ovary syndrome
(PCOS) incidence of the females' reproductive system. The study aim was to explore the prospected effect of
resistin in the development and prediction of PCOS in Al-Kut resident women.
Methods:Forty-six females with PCOS and 40 healthy controls aged (18-40 years) were enlisted in this current
research. The identification of the PCOS was reliant upon the Rotterdam 2003 criteria. Serum resistin,
anthropometric, and biochemical parameters of PCOS were measured for all participants.
Results: Patients with PCOS displayed significantly elevated levels of serum resistin (P<0.001) than controls,
and higher levels in overweight and obese females with PCOS. Resistin, in PCOS patients, correlated positively
with the obesity, IR, and parameters of PCOS, and negatively with HDL and FSH levels. The ROC curve
unveiled greater AUC (0.891) with sensitivity and specificity (80.4% and 94.5%, respectively) for diagnostic cutoff
value (>17 ng/ml) of PCOS.
Conclusion:The association of resistin with the development of IR and obesity giving resistin a viable role in the
PCOS pathogenesis and a novel biomarker for recognition and prediction of PCOS, particularly in obese
females.
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| Keyword:
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resistin, polycystic ovary syndrome, insulin resistance.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.662
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| Download:
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