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Efficacy of Commercially Available Oral Antimicrobial and Topical Anesthetic Gels against Streptococcus mutans
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| Author:
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SHABANA BOWSIYA, DEEPA GURUNATHAN, MADHU SUDHAN VASANTHARAJAN, MURALIDHARAN, DR.LAKSHMI.T
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| Abstract:
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Introduction: Oral ulcers are among the most common oral lesions, having a frequency of 5–25% and three- month recurrence rates as high as 50%. Aphthous ulcer can be described as round or oval, with a grayish yellow, crateriform base surrounded by an erythematous halo of inflamed mucosa. The American Academy of Oral Medicine (AAOM) has recommended topical treatments for oral conditions. Topical medications include anesthetics, antihistamines, antimicrobials, and anti-inflammatory agents. Topical agents address the primary goals of RAU therapy, including reduction in ulcer pain and duration, while decreases in ulcer frequency and prolongation of remission remain elusive. They are efficient in treating minor ulcers, whereas systemic interventions are used in patient is unresponsive to topical agents.
Materials and method: Lignocaine, Metronidazole, Chlorhexidine gluconate
The antimicrobial activity of gels were determined by agar well diffusion method. In this method, Mueller Hinton agar plates were streaked with 0.5 McFarland standard of Streptococcus mutans. The test samples were placed in the wells. These plates were then incubated at 37°C for 24h. The antimicrobial efficacy was then evaluated by measuring the diameter of the zones of inhibition in mm of the two wells and an average of it was recorded.
Result: The topical antimicrobial gels namely, chlorhexidine gluconate and metronidazole, gave a mean zone of inhibition of 20.5mm and 20mm, respectively whereas topical anesthetic gels, namely, lignocaine and benzocaine gave a mean zone of inhibition of 0mm and 14mm respectively against Streptococcus mutans.
Conclusion: The availability of a drug with anesthetic and antimicrobial property is of much advantage to patient and the medical professionals. Further studies can help us understand and treat oral ulcers effectively and minimize the occurrence.
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| Keyword:
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anesthetic, antimicrobial, Lignocaine, benzocaine, chlorhexidine, metronidazole
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.634
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