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Synthesis, Characterization of Diazepine-Bicycles System and Study of their Bio-Behavior
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| Author:
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DR. NAGHAM MAHMOOD ALJAMALI, RABAB MAHDI UBAID MAHMOOD
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| Abstract:
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Benzodiazepines have psychotropic, sedative, hypnotic, anxiolytic, anticonvulsant, muscle relaxing, and amnesic effects, so they are beneficial for a variety of symptoms such as alcohol dependence, seizures, anxiety disorders, panic, agitation and insomnia., most of them are given orally. The target in this study is synthesis of bicycles from Diazepine by cyclization step in two paths (from reaction of Oxazepine compound with and primary amine, or via reaction of imine compound with phthalamide, or via reaction of Diazepine with other amine by insertion reaction to yield other Diazepine from new type. All prepared compounds investigated by types of instrumental methods like (FT.IR, H.NMR, Mass)–spectrophotometric, other chemical characterization, with evaluation of formatted compounds as antibacterial compounds.
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| Keyword:
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Diazepine, Imine, Bicycles, Oxazepine, Antimicrobial, Cyclic, Heterocyclic.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.633
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| Download:
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Request For Article
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