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Core-Shell Nanoparticle Epigallocatechin-3-Gallate and Hyaluronic Acid as Absorbable Dressing Based Hydrogel Post-Gingivectomy: A Review
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| Author:
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MARTINING SHOFFA PUSPITANINGRUM, MOHAMMAD ALI MAKSUM, DEVY PUTRI KUSUMAWARDHANI, ALEXANDER PATERA NUGRAHA
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| Abstract:
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Background: Gingival-enlargement (GE) is enlargement of gingiva which reaches to the tooth cervical due to
inflammation or fibrotic enlargement. Gingivectomy, an excision and incision procedure of gingival tissue for
fibrotic GE patients to eliminate pockets and restore normal gingival contour. Periodontal-dressing is a postgingivectomy wound-dressing to promote healing in plasticine-like form which may cause discomfort because it
stands-out on patient's gums. In addition, some periodontal-dressing contains eugenol, causing necrosis and
allergies. Therefore, a material is needed periodontal-dressing which potentially accelerates post-gingivectomy
wound healing. Combination of Epigallocatechin-3-Gallate (EGCG) and hyaluronic-acid (HA) is biomaterial which
can be obtained easily and potentially as antibacterial, antioxidant and anti-inflammatory in post-gingivectomy
wounds and may accelerate wound healing. Hydrogel is a crosslinking polymer in colloidal-gel form which
easily absorbs by gingiva.
Purpose: to review the potential of core-shell nanoparticles EGCG and HA as absorbable-dressings based
hydrogel to accelerate post-gingivectomy wound healing.
Discussion: Gingivectomy is a lateral wall pocket elimination procedure at GE to restore normal gingival
contours. HA is a natural polymer which is non-toxic, biodegradable, and biocompatible which may stimulate
cell migration, angiogenesis, reduce inflammation, and enhance fibroblast proliferation. EGCG is 80% catechin in
green tea which has antioxidant, anti-inflammatory, and antibacterial effects. EGGC may induce fibroblast
proliferation in gingiva, inhibit free-radicals, also induce VEGF and FGF2. Periodontal-dressing in hydrogel form
is able to comfort patient because it is absorbable and may maintains moist environment.
Conclusion: Core-shell nanoparticle EGCG and HA potentially to be absorbable-dressing based hydrogel to
accelerate post-gingivectomy wound healing.
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| Keyword:
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Epigallocatechin-3-Gallate, hyaluronic acid, core-shell nanoparticles, periodontal dressings, wound healing.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.549
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| Download:
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