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Design and Evaluation of Solid Self-Emulsifying IBUPROFEN Pellets with Commercial Available IBUPROFEN Tablets
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| Author:
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KALAISELVI R, C.SAI KISHAN, KOWSALYA N, AFRASIM MOIN, SIDDARAMAIAH, D.V.GOWDA
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| Abstract:
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Aim: The aim of the study was to design the Solid self emulsified sustained pellets (SSEP), by extrusion/spheronization method loaded with Ibuprofen (IBP), to evaluate the enhanced solubility of IBP. Ibuprofen acts as an Non- Steroidal Anti-Inflamatory Drug (NSAID) in the self emulsifying delivery system, MCC & Badam gum as a polymer at a varied concentration.
Methods: Prepared pellets having sufficient mechanical strength from Extrusion/Spheronization technique. Here developed the liquid mixture consist of IBP, polyethylene glycol, Tween80,Cremophor® RH40 and Transcutol® P. Prepared solid mixture consist of liquid mixture, crospovidone used as a binder, MCC and Badam gum. Miglyol® 812, where tween80 and Transcutol® P used as surfactant & Co-surfactant, respectively. The evaluation parameters carried out for the prepared pellets includes particle size and shape of the pellets, crushing strength and disintegration time, entrapment efficiency, swelling studies, and drug release kinetics.
Result: Obtained results showed that prepared IBP pellets with 25% of the liquid mixture were prepared by extrusion/ spheronization technique. Drug loaded pellets exhibits a uniform size, spherical shape with required hardness. It was observed that droplet size distribution of the IBP pellets same as to the liquid mixtures, In vitro dissolution studies showed that drug loaded from the SSEP was much greater than the conventional tablets. To produce pellets with good quality, by using less ratio of MCC and the more amount of liquid mixture before producing pellets, the preparation process and physical characteristics of the SSEP. It will be improved to a large extent.
Conclusion: It was concluded that the formulation showed some attention should be paid to the retarding effect of physical adsorbents on the release of liquid from pellets, and then the oral absorption performance in vitro.
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| Keyword:
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Ibuprofen, Pellets, Solid emulsified tablets, Release studies
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.589
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| Download:
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