|
Synthesis and Antifungal assay of Analogs Curcumin: Dibenzilyden-N-Methyl-4-Piperidone and Dibenzilyden-4-Piperidone
|
|
| Author:
|
RITMALENI , TESIA AISYAH RAHMANIA, PRASHINTA NITA DAMAYANTI, ERNA PRAWITA SETYOWATI
|
| Abstract:
|
The increase in populations of candidiasis and candidemia patients requires more antifungal agents, but the increased use of antifungal agents also resulted in the development of resistance to the present drugs. It makes necessary to discover and development of new antifungal agents. This research is aimed to synthesis new fungicidal agents from analogs curcumin that focused on monocarboyl analogs curcumin that have piperidone ring containing nitrogen atoms. The Claisen-Schmidt condensation reaction was used in acid or basic condition. All the compounds showed light yellow to yellow crystal with percentage of yield 39, 41, 72 and 44% respectively. All the structure compounds were confirmed by using IR, 1H-NMR, 13C-NMR, and MS. The synthesis was evaluated antifungal activity against Candida albicans (ATCC 10231) using disc diffusion method. The antifungal results showed that E125 and E144 compound has inhibition on concentration 500??g/mL and 250??g/mL. None of the tested compounds was as active as the reference standard drug Nystatin.
|
| Keyword:
|
fungicidal agents, analogs curcumin, piperidone ring
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2021.13.01.543
|
| Download:
|
Request For Article
|
|
|