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A Review on Liquisolid Technique in the Preparation of Oral Disintegrating Tablets
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| Author:
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VISHRATH N, PREETHI S, SHEETAL MJ
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| Abstract:
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For about one third of drugs in their production process, solubility is a big concern. Liquisolid technology is one
of the most effective and promising strategy for enhancing the solubility and dissolution. This technique is
used for upgrading the disintegration of inadequately water-soluble drugs by converting the liquid drug into
powder form that is suitable for tableting. It is obtained by blending the suspension of the API with excipients
known as carrier and covering agents. This technique increases dissolvability and absorption of API by suspending
in its molecularly scattered form that leads to its increased bioavailability, free-flowing property and results in
compactable powder mixtures. As improving the bioavailability of such drugs stays a difficult task for formulators,
this liquisolid technology serves as a promising technique to overcome the poor solubility and dissolvability
concerns.
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| Keyword:
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Bioavailability, Liquisolid, Carrier, coating agent, solubility, disintegrating
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.322
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| Download:
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