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Development of Esomeprazole Mucoadhesive Timerx Tablets
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| Author:
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EBY GEORGE, ANJALI K BIJU, FATHIMA MEETHIAN, LINTA BENNY, SUVARNA VARGHESE
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| Abstract:
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The recent advances in the emergence of gastro retentive controlled drug delivery systems envisages the
development of mucoadhesive controlled release tablets for the treatment of gastric ulcers. The present work
deals with the formulation and evaluation of mucoadhesive controlled release tablets containing Esomeprazole
magnesium trihydrate prepared by TIMERx technology. The blend of TIMERx polymers, Xanthan gum and
Locust bean gum enhanced the duration of drug release in more controlled way. A total of six formulations
namely F1,F2,F3,F4,F5 and F6 tablets were prepared by TIMERx technology containing bioadhesive polymers
like Chitosan, Carbopol 974P, Polyvinyl pyrrolidone, Sodium Carboxy methyl cellulose, Sodium Alginate and
Polaxomer respectively. The prepared tablets were subjected to pre and post compression evaluation studies.
The flow properties were shown to be excellent for all powder blends assessed from their Carr’s Index values.
F4 showed maximum hardness whereas F4 and F5 showed maximum mucoadhesion time with minimum
swelling index. Considering mucoadhesion time, swelling index and mucoadhesive strength, F5 was selected
and subjected to in-vitro dissolution studies and kinetic data analysis, which are then compared with the
marketed controlled release tablets of Esomeprazole.F5 showed the maximum cumulative percentage release
of 64.20% following zero order release kinetics, whereas marketed formulation showed a release of 36.62%
after 8 hours.F5 had proved to be the best candidate considering maximum percentage drug release in
controlled pattern, Mucoadhesion time and strength which are the pre-requisite properties of Esomeprazole,
potentially decreasing gastric acid secretion in peptic ulcer patients.
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| Keyword:
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Sodium alginate, TIMERx, Esomeprazole, Locust bean gum, Xanthan gum
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.566
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| Download:
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