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Design and invitro evaluation of olmesartan medoxomil floating tablets
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| Author:
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SACHIN B AGLAWE, AMOL U GAYKE, RAVINDRA S DUKARE, RAHUL A SOMWANSHI, SATYAM D JAIN, VINOD V ANUSE
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| Abstract:
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The present study aimed to a develop controlled release floating drug delivery system (FDDS), which will remain in the stomach for a longer time while controlling drug release to achieve target release profile using a combination of hydroxy propyl methyl cellulose of different grades and carbopol, hydroxy propyl cellulose as polymer. Sodium bicarbonate was incorporated as gas generating agent. Floating tablets of olmesartan medoxomil were prepared by direct compression method. All the floating tablets formulations were subjected to precompression and post-compression parameter evaluation. All the tablets were subjected to weight variation, hardness, friability, dissolution, swelling index, floating properties, drug release studies and drug excipient interaction studies. The tablets were found to be good in their integrity without any chipping, capping and sticking. IR-spectroscopicand DCS studies indicated that there are no drug–excipients interactions. Formulation F9 showed good result than rest of the formulations according to targets obtained. Invitro dissolution studies were also performed for all formulations, formulation with HPMC K15M i.e F9 showed the controlled release for 16hr.
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| Keyword:
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Olmesartan medoxomil, Hypertension, Floating tablet.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.534
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| Download:
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