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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Comparison Of Gas Man® Simulated Low Flow Anaesthesia With Real-Time, Using Sevoflurane - Air Oxygen Mixture

Author: DR.RAVISHANKAR.M, DR.BALASUBRAMANIAN ANUSHA, DR, VR HEMANTH KUMAR, DR.S.PARTHASARATHY
Abstract: Background & Aims: Gas Man simulation software has not been validated on humans using sevoflurane – air-oxygen mixture. This study was undertaken to see the predictability and correlation of the Gas Man software with the real time measured sevoflurane concentration in air oxygen mixture. Methods: After obtaining ethical committee approval and informed consent, thirty ASA 1 and 2 patients of either sex, between 20 - 50 years were selected. Gas Man simulation was done prior to anaesthetizing the patients. The inspired (FiSevo) and end-tidal concentration (EtSevo) of sevoflurane values were generated every minute. The anaesthesia induction was done by a standard protocol, maintained with low flows (air + O2 mixture and sevoflurane) and semi closed circle system with same fresh gas flows and dial setting of vaporizer as Gas Man simulation. The FiSevo and EtSevo values were collected every minute. The model performance was assessed Varvel’s criteria. Results: The median absolute performance error (FiSevo=10.22%,EtSevo=12.12%), median performance error(FiSevo= -3.67% ,EtSevo= -4.96), wobble (FiSevo= 12.01%, EtSevo=14.40%) and divergence(FiSevo = 0.09%, , EtSevo = 0.19%) were comparable. Conclusion: The FiSevo and EtSevo predicted by Gas Man were close to real patients.
Keyword: Gas Man, Real Time, Inspired Sevoflurane, End Tidal Sevoflurane
DOI: https://doi.org/10.31838/ijpr/2021.13.01.533
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