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Repurposing of Drugs: Progress, development approaches and challenges
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| Author:
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RASANPREET KAUR, AKSHATA MANDLOI, SUDARSHAN SINGH LAKHAWAT, DESH DEEPAK SINGH, SUNIL KUMAR, VIKRAM KUMAR
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| Abstract:
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Drug repurposing approach is emerging to overcome the limitations of de novo drug discovery and development in fields of financial support, timeline and resources. Drug repositioning exploits the previously obtained clinical trials data for toxicity and adverse effects, and at the same time investigate the drug's therapeutic potential for another disease. Academia and research institutes, pharmaceutical companies and repurposing technology companies are the major key players in the field of drug repurposing. Various computational and experimental approaches help in the process of drug repurposing. An effective repurposing conduit involves the permutation of access to molecule data, suitable analytical skills to facilitate robust visions, expertise and experimental set up for validation, and clinical development. Compound identification arises from inspection of large libraries of active compounds, interrogating different databases or unifying several types of information regarding disease–drug correlations. In silico approaches like docking techniques evade the tedious in vitro and in vivo techniques implicated in former screening phases of the drugs and disease specific targets. However, there are various technological and regulatory challenges that need to be tackled.
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| Keyword:
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Drug repurposing, Clinical trials, Drug discovery, Safety, Efficacy
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.529
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| Download:
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Request For Article
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