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The Effectiveness of Walnuts Extract and Metformin on Blood Sugar Level Reduction in Hyperglycemic Induced Alloxan Rats
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| Author:
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NURHAEDAR JAFAR, NURSYAFITRI RAMADANI, NURPUDJI A TASLIM, HEALTHY HIDAYANTY, AMINUDDIN SYAM, YAHYA THAMRIN
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| Abstract:
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This study aims to determine the effectiveness of walnut extract (Canarium indica) and metformin in reducing blood sugar level of Wistar rats (Rattus norvegicus ) induced by alloxan. Experimental research was conducted with pre-post test control group design. The sample in this study were 28 rats induced by alloxan to become hyperglycemic. The test animals were divided into four groups, each consisting of seven: negative control (Na CMC 1%), positive control (metformin 150 mg/kg BW), walnut extract group 300 mg /kg BW (60mg/200gr BW), and extract 600 mg /kg BW (120mg/200gr BW). The intervention was given walnut extract for 21 days. Blood sugar level was analyzed using Autocheck Multi-Monitoring System on day 0, day 3, day 6, day 24, and day 27 and analyzed using spss with paired t-test and ANOVA test. This research was conducted with the permission of the Ethics Committee of the Hasanuddin University Faculty of Public Health with number: 2584 / UN.4.14.1 / TP 01.02 / 2020. The results showed a significant reduction in fasting blood sugar level in all groups (p <0.05). There was a significant decrease in blood sugar level between the four groups (p = 0.006). The highest reduction in blood sugar level was in the extract group 600mg/kg BW (301.0 mg/dl), then positive control(KP) group (metformin 150mg/kg BW) (288.5 mg/dl), extract 300 mg/kg BW (247.71 mg/dl), and the lowest decrease in thenegative control(KN) group (Na CMC 1%) (41.55 mg/dl). In this study, found no significant differences between walnut extract and metformin in order decrease blood fasting glucosa level. In conclusion walnut extract has the same effectiveness as metformin. The intervention of walnut extract for 21 days was able to reduce blood sugar level in alloxan-induced hyperglycemic rats, starting with a dose of 300mg/kg BW to 600mg/kg BW.
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| Keyword:
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Alloxan, Walnut Extract (Canarium indica), Hyperglycemic, Rat
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.554
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| Download:
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