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Spectral and Thermodynamic Study of Amoxicillin Drug with Surfactant SLS In Presence of Silver Nanoparticles
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| Author:
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LIQAA HUSSEIN ALWAN, HIND AHMED MAHMOUD
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| Abstract:
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The study included the preparation of nanoparticle Silver and it was diagnosed by UV-Vis absorption spectroscopy ,SEM, TEM and EDX. In this work , the studied the factors influencing the formation of micelles through of different concentrations of Amoxicillin an absorption maximum was found to be at (?max=274nm) 50-1000µg.ml-1 and at temperature ranges (10 – 45Co). The developed method was validated with respect to linearity, limit of detection (LOD), limit of quantitation (LOQ), Sandall's sensitivity, the molar absorptivity. Beer's law was obeyed in the concentration range of 50-800µg.ml-1 having line equation y =0.0006x +0.0302 with correlation coefficient of 0.9991. Through the viscosity (? pa.s) measurements for mixture of (Amox. / SLS :Ag) and at ratios of ( 2,4,5,6,8 and 10 ) , were increased in the presence of Silver nanoparticles (0.0004M) due to formation of micelles , moreover ; the thermodynamic faction ( ?G°, ?H and ?S° ) were calculated for the process of micelles formation because assembled supramolecular (by Intermolecular interaction and high surface areas for nanoparticle ) of Amox./SLS in Ag nanoparticle , the negative sign of ?G° indicated that micellazation of Amox./SLS:Ag mixture was spontaneous process , the negative values of ?H signified that the micellazation is exothermic process and the negative values of ?S° reflect that decrease in randomness in liquid during the micellazation was undertaken. Conductivity ( L µS.cm-1 ) measurements were also causing for further obligation the results revealed a phys.-interaction prudence inter-molecular forces .
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| Keyword:
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SNPS, SLS, Spectrophotometric, Conductivity, Thermodynamic, Intermolecular.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.627
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| Download:
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