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Role of Flavonoid Rich Fraction of Butea monosperma Linn. In Memory Enhancing Activity
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| Author:
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GHASSAN SALAH AHMED, MAZIN A.A.NAJM , AHMED S.ABDUL JABBAR, FALAH HASSAN SHARI
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| Abstract:
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Aim: The main of the present study is to find out the Role of Flavonoid Rich Fraction of Butea monosperma Linn. In Memory Enhancing Activity.
Material & Methods: The dried powder of flowers was extracted and Flavonoid-rich fractions were prepared by the prescribed method. The quantitative phytochemical test for the occurrence of various active phytoconstituents was performed for the presence of phenolic and flavonoid compounds. The acute toxicity study was also performed for dose determination. The antioxidant activity of Flavonoid fraction was performed by different methods i.e. DPPH, Hydroxyl radical, and carotene method. The Flavonoid fraction was evaluated for the memory-enhancing activity by Morris test and elevated plus maze and at the end of the study, cholinesterase level in brain was estimated. RESULTS: The result showed that Flavonoid fraction extract reserved ß-carotene/lin¬oleic acid oxidation and progressive action happening beside by concentration. Hydroxyl radical scavenging ability calculated as IC50 reveals that Flavonoid fraction has IC50 values of 48 µg/mL respectively. DPPH scavenging ability calculated as IC50 shows that Flavonoid fraction has IC50 of 38 µg/mL followed by ascorbic acid (3.4 µg/mL). Flavonoid fraction significantly decreased (P<0.001) EL and significantly increased TSTQ as compared to vehicle-treated control. Oral administration of Flavonoid fraction in 25 and 50 mg/kg, respectively exhibited significant (P < 0.01) increase in the percentage of the number of open arm entries and time spent in open arm whereas, in the closed arm number of entries and time spent was significantly (P < 0.01) reduced as compared to vehicle-treated group.
Conclusion: The results obtained in this study have exposed that Flavonoid fraction displayed significant memory enhancing activity.
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| Keyword:
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Flavonoid Rich Fraction, Butea monosperma Linn., Memory Enhancing Activity, Morris Water Test, Cholinesterase Enzyme
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.626
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| Download:
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