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The Inhibition of Food Intake by Peptide YY (PYY)
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| Author:
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AZHAR DZULHADJ B. ARAFAH, BURHANUDDIN ARAFAH, AZHARIAH NUR B. ARAFAH, FAJRIAH RAHMAH B. ARAFAH
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| Abstract:
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The focused treatment of obesity in reducing body weight can be achieved through the control of peptide hormones regulating energy homeostasis. Peptide Tyrosine Tyrosine/Peptide YY (PYY), a 36-amino acid peptide composed of carboxyl and amino acid terminal tyrosine, is mainly secreted from the enteroendocrine L-cells of the lower gastrointestinal tract due to direct luminal-contact of nutrients as well as neuroendocrine pathways. The binding process of PYY to its NPY receptors forms a PYY-NPY receptor complex and will trigger the control of energy balance through the inhibition of gastric enzymes secretion as well as deceleration of gastric emptying. PYY is a potential agent in inhibiting food intake and therefore a promising target in the development of novel therapeutic strategies for obesity. This article reviews the characteristics of PYY; the effects of exogenous administration of PYY; the effects of macronutrient composition on PYY secretion; and the possible role of PPY being more than just an appetite regulator that could act as a breakthrough for the treatment of obesity.
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| Keyword:
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peptide,inhibition
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.592
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| Download:
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