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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The Role Of Diffusion Weighted Imaging With Background Signal Suppression (Dwibs) In Diagnosis Of Breast Lesions: Comparison With Contrast Enhanced Digital Mammography (Cedm)

Author: FATMA SABER ELSAYED SINGER, SOHA TALAT HAMED, NOHA ABDELSHAFY ELSAID, MARWA ANAS ABDLRAHMAN
Abstract: Background: Investigation aim was assessment the diagnostic performances and diffusion weighted imaging accuracies with background signal suppression comparing to contrast enhanced mammography in diagnosis of breast lesions and correlate the findings with the histopathological results Results: 52 female enrolled in our investgatin; mean ages about (47.83) years, 54 lesions detecting in 52 patients.39/54 of lesions are histopathologically proven as malignant and 15/54 benign. Overall mammography sensitivities, CEDM and DWIBS-MRI were 92.3%, 100% and 94.90%, respectively .Their specificity was 60%, 73.30% and 93.30% respectively. Area under ROC curve has higher of DWIBS MRI (97.4%) than that was in CEDM (90.4 %) by used BIRADS analysis. Therefore, DWIBS was the best in breast lesions characterization. The cut off value of ADC fwas suggested to be 1.15 × 10-3 mm2with sensitivity of 94.90%, specificity of 80%The AUC was (AUC) = 0.913 with (95% Confidence Interval).Conclusion: DWIBS is less sensitive but more specific compared to CEDM in the characterization of both malignant and benign lesion by BIRADS. It can improve breast cancer detection rates correlated with T2 morphology and subsequently advance towards a new non-contrast MRM examination. Contrast enhanced digital mammography (CEDM) is feasible and has an important role in evaluation of equivocal breast lesions d improving its sensitivity and specificity
Keyword: Contrast mammography- BIRADS- Breast- Lesions –DWIBS MRI-ROC-ADC54
DOI: https://doi.org/10.31838/ijpr/2020.12.04.590
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