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Design And Development Of Gemcitabine Nanoemulsion For Pulmonary Delivery
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| Author:
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MERRYL D’SILVA, AFRASIM MOIN, RACHNA.M .KUMAR, SIDDARAMAIAH, D.V. GOWDA
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| Abstract:
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Objective: Gemcitabine a synthetic pyrimidine nucleoside prodrug with antineoplastic activity. In this study Gemcitabine (GM) nanoemulsion (NE) was developed and evaluated for pulmonary delivery.
Method : GM loaded NE was prepared with cremophor RH 40 (oil), PEG 400(co-surfactant) and labrafil M2125Cs(surfactant )in a ratio of 2:1:1. The formulations were evaluated for particle size, zeta potential, pH, in-vitro drug release, rheology studies, and conductivity.
Result: The particle size of the blank and drug-loaded NE was found to be 22 nm. The pH of the prepared formulations was well within the limit (6.35 ± 0.02 to 7.01 ± 0.002). The optimized formulation was sterilized by aseptic filtration. From the polarized light microscopy study, the isotopic nature of optimized NE formulation was confirmed. The drug entrapment efficiency and the in-vitro drug release was found to be 89% and 93% respectively. The optimized formulation M2 was found to be stable from the stability studies.
Conclusion: The optimized formulation M2 was found to be stable and can be potentially used in pulmonary delivery.
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| Keyword:
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Gemcitabine, Nano emulsion, Pulmonary drug delivery
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.563
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| Download:
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