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Maerua oblongifolia (Forsk.) A. Rich. Extract Loaded Floating Microballoons: Advance Therapy to Treat and Manage Gastric Ulcer
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| Author:
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RANJITHA M, UMA, NITHYASHREE RS, SHOUVIK KUMAR D, SASIPRIYA SVS, TANMOY GHOSH, KAMATCHI SUNDARA SARAVANAN, MOHAMMAD AZAMTHULLA
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| Abstract:
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Purpose: This study aimed to develop floating microballoons loaded with Maerua oblongifolia (Forsk.) A. Rich. root aqueous extract (FMMO) and to evaluate its anti-ulcerogenic activity in Wistar Albino rats.
Methods: FMMO was prepared by solvent evaporation method and its size, floating time, buoyancy percentage were determined. Oral acute toxicity of FMMO was assessed following OECD (423) guidelines. In-vivo anti-ulcer efficacy was evaluated in indomethacin, pylorus ligation, and cysteamine induced ulcer model.
Results: The yield to solvent of M. oblongifolia root was 20% w/w with carbohydrates, proteins, amino acids, and glycosides as its major bioactives. Optimized FMMO displayed spherical shape as expected with average size of around 300µ diameter and in-vitro buoyancy of 75% at 10 h. Oral acute toxicity study exhibited neither toxic symptoms nor mortality at 2000 mg/Kg of FMMO, hence further anti-ulcer evaluation was progressed using 100 and 200 mg/Kg body weight. FMMO presented gastric ulcer healing, gastric anti-secretory effect in pylorus ligation model; gastric cytoprotective effect in indomethacin induced gastric ulcer and significant reduction in duodenal ulcers.
Conclusion: An enhancement of gastric ulcer healing was observed with FMMO in indomethacin induced ulcers. Concurrently, FMMO also demonstrated a preventive action on development of gastric and duodenal ulcers in experimental animals.
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| Keyword:
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Floating microballoons, Maerua oblongifolia, Indomethacin, Cysteamine, Pylorus Ligation
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.541
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| Download:
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