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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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A Review on Prominent Biomaterials Employed in the Management of Diabetic Wounds

Author: SURAJ S, PREETHI S, AMIT B PATIL, VIKAS JAIN
Abstract: Purpose: Diabetes mellitus (DM) is caused due to higher levels of blood sugar in the body which is due to deficiency of the hormone; insulin and its impaired function. Among the complications associated with DM, wound healing is a prominent issue. Healing of wounds occurs by replacement of the damaged cells and tissue layers through coordination of cell migration and proliferation, deposition of the extracellular matrix, and remodeling of tissues. The presence of Diabetes mellitus makes the condition even worse by inhibiting or delaying the healing cascade and often results in untimely and inefficient wound recovery. In the present scenario, a wide range of biomaterials is being exploited to form an effective strategy for the management of diabetic wounds. The review was carried out to explore the potentiality of novel biopolymers, metal nanoparticle impregnated biomaterials, and fabricated dressings to alleviate the condition. Methods: This article outlines the employment of diverse natural biopolymers, their use and applications of the biopolymers in the fabrication of wound dressings that aid the management of diabetic wounds. Results/Outcome: On review of various published research literature, the natural biopolymers used to manufacture the wound dressings showed promising results in the successful management of diabetic wounds. Conclusion: On the assessment of various therapeutic outcomes of the fabricated wound dressings, the natural biomolecule sources were found effective for managing diabetic wounds.
Keyword: Diabetes mellitus, Wound, Biomaterials, Biopolymers, Nanoparticle, Fabricated dressings.
DOI: https://doi.org/10.31838/ijpr/2021.13.01.462
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