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Spectrophotometric determination of metronidazole benzoate in pharmaceutical dosage forms
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| Author:
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DHURGHAM QASIM SHAHEED , QASIM A.BADER, ALAA ABDULHASAN ABBAS
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| Abstract:
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Background: Metronidazole is a routinely prescribed and heavily utilized antibiotic. This drug has been manufactured in many pharmaceutical dosage forms to treat various and serious infections. Hence, the determination of this vital drug is of an established importance. The UV-Visible protocol is commonly utilized machine for drugs in both active form and in pharmaceutical preparations. The standard addition procedure combined with UV visible instrument has shown a well-defined protocol to be followed and applied for metronidazole quantification procedures.
Methods: Three of the widely available pharmaceutical dosage forms of metronidazole were chosen and analysed. These pharmaceutical dosage forms are tablets, vials, and oral suspensions. The samples were handled with modified USP guidance and reasonably diluted and inoculated with the metronidazole standard solutions. The UV readings were observed and the standard curves were plotted.
Results: The observed curves show well-fitted straight lines for the all three pharmaceutical preparations (i.e. tablets, vials, and suspensions). The coefficients of regressions were found 0.9982, 0.9993, 0.9996, for tablets, vials, and suspensions, respectively. Consequently, the contents percentages for the metronidazole tablets, vial, suspensions were recorded as 100.6%, 102.4%, and 99.5%, respectively.
Conclusion: It can be concluded that this protocol is fit for the quantification purposes for the assessment of percent contents of metronidazole in various pharmaceutical preparations.
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| Keyword:
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Standard addition method, Metronidazole benzoate, Metronidazole tablets, Metronidazole vials, Metronidazole suspensions.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.497
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| Download:
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