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An Overview of Cocoa Butter: Novel Excipients for Oral Tablets
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| Author:
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PEARLY CHIA ZHI QING, ASHOK KUMAR JANAKIRAMAN, SHIEK ABDUL KADHAR MOHAMED EBRAHIM HABIBUR RAHMAN, LIEW KAI BIN
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| Abstract:
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Cocoa butter (CB) is an essential component of chocolates, which was used up to 40% as maximum. Cocoa butter has been used as a food flavour, cosmetics, suppositories additive and various biomedical applications for a longer period. Application of cocoa products as pharmaceutical excipient expanded in recent times in pharmaceutical product development. Particularly cocoa butter’s melting and lubricant activity gained attention from researchers for developing oral disintegrating tablets (ODTs) or fast melting tablets (FMTs). Fast melting tablets are oral tablets formulations without the need for chewing or swallowing it with or without water. This dosage form helps to solve the limitations of dysphagia in all populations but especially for geriatrics and paediatrics. Cocoa butter is a readily available lipid that melts at body temperature 37°C. Cocoa butter has many polymorphisms and form V cocoa butter is the preferred stable form. This review explored the application of cocoa butter in pharmaceutical tablet dosage form development and its approved patent.
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| Keyword:
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cocoa butter, excipient, orally disintegrating tablets, fast melt tablets, oral tablets
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.373
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| Download:
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